Use of ITIH1 as biomarker for detection of insulin resistance in diseases accompanied by impaired glucose tolerance

A method for detecting an ITIH1 biomarker,

• the method comprising:
• detecting presence and/or a concentration of a protein of the ITIH1 biomarker from a biological sample derived from a test subject in order to provide information necessary for diagnosis or prognosis of a disease accompanied by impaired glucose tolerance;
• comparing a result of detection for the presence and/or concentration of the protein with a result for a corresponding marker in a normal control sample;
• and
• determining that there is a disease accompanied by impaired glucose tolerance when, compared to the normal control sample, there is a change in the concentration of protein in the sample derived from the subject, or there is a change with regard to presence or absence of the protein,
• wherein the detecting the presence and/or concentration of the protein is performed using an antibody or the antigen-binding fragment thereof, and
• the antibody or the antigen-binding fragment thereof comprises:
• a light-chain variable region comprising complementarity-determining regions CDRL1, CDRL2, and CDRL3 set forth in SEQ ID NOS:
• 1, 2, and 3, respectively, and a heavy-chain variable region comprising complementarity-determining regions CDRH1, CDRH2, and CDRH3 set forth in SEQ ID NOS:
• 4, 5, and 6, respectively;
• or
• a light-chain variable region comprising complementarity-determining regions CDRL1, CDRL2, and CDRL3 set forth in SEQ ID NOS:
• 7, 8, and 9, respectively, and a heavy-chain variable region comprising complementarity-determining regions CDRH1, CDRH2, and CDRH3 set forth in SEQ ID NOS:
• 10, 11, and 12, respectively.