Fused polypeptide with multifunctional activities and use thereof
AssigneeNanjing Anji Biological Technology Co., Ltd.
InventorHanmei Xu
Life of this patent
Estimating the term…
Abstract
The present disclosure discloses use of a fused polypeptide with multifunctional activities. In the fused polypeptide with multifunctional activities, the polypeptide contains the following domains: Pro-Arg-Cys-X-Y-Gly-Glu, where X is Trp or Tyr, and Y is Arg or Cys; and Gly-Gly-Gly-Gly-Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-Gly-Gly-Arg-Gly-Asp; or a sequence of any amino acid mutated in the foregoing domains. The fused polypeptide can be used for treating various fibrosis diseases and symptoms, including pulmonary fibrosis, hepatic fibrosis, skin fibrosis, renal fibrosis, myocardial fibrosis, and lung tissue lesions.
Claims7
A fused polypeptide with multifunctional activities comprising one of amino acid sequences:
- polypeptide I (SEQ ID NO:
- 1):
- Pro-Arg-Cys-Trp-Arg-Gly-Glu-Gly-Gly-Gly-Gly-Ile-
- Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-
- Gly-Gly-Arg-Gly-Asp;
- polypeptide II (SEQ ID NO:
- 2):
- Pro-Arg-Cys-Tyr-Arg-Gly-Glu-Gly-Gly-Gly-Gly-Ile-
- Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-
- Gly-Gly-Arg-Gly-Asp;
- polypeptide III (SEQ ID NO:
- 3):
- Pro-Arg-Cys-Trp-Cys-Gly-Glu-Gly-Gly-Gly-Gly-Ile-
- Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-
- Gly-Gly-Arg-Gly-Asp;
- and
- polypeptide IV (SEQ ID NO:
- 4):
- Pro-Arg-Cys-Tyr-Cys-Gly-Glu-Gly-Gly-Gly-Gly-Ile-
- Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-
- Gly-Gly-Arg-Gly-Asp.
Dependencies are inferred from the claim text.