Lamp constructs comprising allergens
AssigneeImmunomic Therapeutics, Inc.
InventorTeri Heiland
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Abstract
The present invention provides improved LAMP Constructs comprising specific fragments of the LAMP lumenal domain to deliver allergens to immune cells for enhanced processing. These LAMP Constructs can be used for the treatment of disease and in particular allergic reactions and/or allergies. The improved LAMP Constructs allow for presentation of properly configured three dimensional epitopes for production of an immune response when administered to a subject. The improved LAMP Constructs can be multivalent molecules, and/or can be provided as part of a multivalent vaccine containing two or more LAMP Constructs.
Claims25
A polynucleotide encoding a lysosomal associated membrane protein (LAMP) Construct, wherein the LAMP Construct comprises:
- 1) two homology domains of a luminal domain of a LAMP protein, and
- 2) at least one allergen comprising CryJ1 and/or CryJ2,
- wherein the allergen is placed between the two homology domains.
Dependencies are inferred from the claim text.