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US 12,398,184 B2Granted
Compositions comprising CelTOS immunogens and antibodies and method of use thereof
AssigneesWashington University, University of South Florida
InventorsNiraj Tolia, John Jimah, Nichole Salinas, Darya Urusova, John Adams, Shulin Xu, Allison Roth, Hirdesh Kumar
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Abstract
The present disclosure provides immunogenic compositions and methods for vaccination with a CelTOS immunogen. The immunogenic composition comprises Babesia, Theileria or Cytauxzoon CelTOS. The immunogenic composition may also comprise CelTOS with structural changes that affect immune recognition.
Claims7
An antibody, wherein the antibody comprises (a) a heavy chain comprising a CDR1 comprising the amino acid sequence GYSFTDYN (amino acids 24-31 of SEQ ID NO:
- 79), a CDR2 comprising the amino acid sequence IDPYNGGT (amino acids 49-56 of SEQ ID NO:
- 79), and a CDR3 comprising the amino acid sequence ARGYYYGNPLHFDV (amino acids 96-108 of SEQ ID NO:
- 79);
- and (b) a light chain comprising a CDR1 comprising the amino acid sequence SSVSY (amino acids 26-31 of SEQ ID NO:
- 80), a CDR2 comprising the amino acid sequence DTS (amino acids 49-51 of SEQ ID NO:
- 80), and a CDR3 comprising the amino acid sequence QQWISYPAT (amino acids 88-96 of SEQ ID NO:
- 80).
4 more elements
Dependencies are inferred from the claim text.