SIV envelope trimer
AssigneeThe Scripps Research Institute
InventorsRaiees Andrabi, Dennis Burton
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Abstract
The present application relates to epitope-targeted SIV and HIV vaccines. The invention provides novel envelope glycoproteins which may be utilized as HIV-1 vaccine immunogens, antigens for crystallization, and for identification of broadly neutralizing antibodies. The invention encompasses preparation and purification of immunogenic compositions which are formulated into vaccines of the present invention.
Claims18
An engineered or non-naturally occurring molecule that binds to a Human Immunodeficiency Virus (HIV-1) broadly neutralizing antibody (bnAb),
- wherein the molecule comprises the amino acid sequence of SEQ ID NO:
- 28.
An engineered or non-naturally occurring molecule that binds to a Human Immunodeficiency Virus (HIV-1) broadly neutralizing antibody (bnAb), wherein the bnAb binds to the V2 apex region of HIV-1 envelope, wherein the molecule comprises an amino acid sequence comprising SEO ID NO:
- 28 or an amino acid sequence having at least 95% sequence identity to SEQ ID NO:
- 28.
Dependencies are inferred from the claim text.