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US 12,398,174 B2Granted
Optically verified polymer synthesis
AssigneeThe Charles Stark Draper Laboratory, Inc.
InventorsAndrew P. Magyar, Melissa M. Sprachman
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Abstract
Compositions and methods for optically-verified, sequence-controlled polymer synthesis are described.
Claims13
A monomer unit,
- comprising a bifunctional building block comprising a removable, fluorescently-labeled protecting group;
- wherein the protecting group comprises a boronate analog, a silyl group, or a silyl analog;
- and
- wherein the bifunctional building block is coupled to a peptide nucleic acid (PNA) through disulfide bonds to form a macrocycle.
1 more element
A monomer unit comprising a bifunctional building block coupled to a peptide nucleic acid (PNA) through disulfide bonds to form a macrocycle,
- wherein the macrocycle is fluorescently-labeled,
- and optionally wherein the bifunctional building block comprises a removable protecting group, and the protecting group comprises a boronate analog, a silyl group, or a silyl analog.
Dependencies are inferred from the claim text.