Continuous preparation method for penem intermediate map

A continuous preparation method for a penem intermediate MAP, comprising:

• step S1, in a column-type continuous reactor, using a rhodium-loaded catalyst to catalyze 4-nitrobenzyl(R)-2-diazo-4-((2R,3S)-3-((R)-1-hydroxyethyl)-4-oxoazetidin-2-yl)-3-oxopentanoateto generate a cyclization reaction so as to form a first intermediate, wherein the rhodium-loaded catalyst is loaded in the column-type continuous reactor, and the rhodium-loaded catalyst has the following structural formula:
• wherein R1 represents any one alkyl of C1-C10;
• P—COO— represents a residue of a polymer after dehydrogenation, and x represents an arbitrary number of 0.1-4.0;
• step S2, performing an esterification reaction on the first intermediate, a diphenyl chlorophosphate and a diisopropylethylamine in a second continuous reactor, to obtain a product system containing the penem intermediate MAP;
• and
• step S3, feeding the product system, a quenching agent and crystallization liquid into a third continuous reactor to perform continuous crystallization, to obtain a crystallization system, wherein the quenching agent is selected arbitrary one or more from a group of pure water, potassium dihydrogen phosphate buffer solution, potassium hydrogen phosphate buffer solution, sodium dihydrogen phosphate buffer solution, and sodium hydrogen phosphate buffer solution, and the crystallization liquid is selected arbitrary one or more from a group consist of hexane, heptane, octane, methyl cyclopentane and petroleum ether;
• and
• performing solid-liquid separation on the crystallization system, to obtain the penem intermediate MAP;
• wherein the third continuous reactor is a one-level coiler continuous reactor or a multi-level coiler serially-connected continuous reactor;
• and
• the formula of the penem intermediate MAP is: