Substituted hydantoinamides as ADAMTS7 antagonists

A compound of formula (I):

• wherein,
• R1 is selected from the group consisting of hydrogen, (C1-C6)-alkyl, (C3-C6)-cycloalkyl, 5- to 6-membered heterocycloalkyl, 5- to 10-membered heteroaryl, and phenyl,
• wherein said (C1-C6)-alkyl, (C3-C6)-cycloalkyl, 5- to 6-membered heterocycloalkyl,5- to 10-membered heteroaryl, or phenyl is optionally substituted with one or two groups independently selected from the group consisting of cyano, halogen, amino, hydroxy, oxo, C1-C3-alkyl, (C1-C4)-alkoxy, (C1-C4)-alkylcarbonyl, mono-(C1-C4)-alkylamino, di-(C1-C4)-alkylamino, phenyl, (C1-C4)-alkylsulfonyl, and (C3-C6)-cycloalkyl,
• wherein each said C1-C3-alkyl, (C3-C6)-cycloalkyl, or (C1-C4)-alkoxy is optionally substituted with up to 5 fluorine atoms;
• R2 is selected from the group consisting of hydrogen, cyano, halogen, (C1-C4)-alkylsulfonyl, (C1-C4)-alkyl, (C3-C6)-cycloalkyl, and (C1-C4)-alkoxy,
• wherein said (C1-C4)-alkyl, (C3-C6)-cycloalkyl, or (C1-C4)-alkoxy is optionally independently substituted with up to five fluorine atoms, cyano, or (C1-C2)alkyl,
• wherein said (C1-C2)alkyl is optionally substituted with up to five fluorine atoms;
• R3 and R4are each independently selected from the group consisting of hydrogen, halogen, (C1-C4)-alkyl and (C1-C4)-alkoxy, wherein each said (C1-C4)-alkyl and (C1-C4)-alkoxy is optionally independently substituted with up to five fluorine atoms,
• provided that at least one of R2, R3, and R4 represents H;
• X1, X2, X3, X4, X5, and X6 are each independently N or C, provided that in each ring system maximally one X stands for N;
• and
• R5, R6, R7 and R8 are each absent when the X atom to which they are attached is N, or
• R5, R6, R7 and R8 are each independently selected from the group consisting of hydrogen, halogen, (C1-C4)-alkyl and (C1-C4)-alkoxy when the X atom to which they are attached is C,
• wherein each said (C1-C4)-alkyl and (C1-C4)-alkoxy is optionally independently substituted with up to five fluorine atoms present,
• or a pharmaceutically acceptable salt thereof, a solvate thereof, or a solvate of a pharmaceutically acceptable salt thereof.