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US 12,398,115 B2Granted
Chrysophaentin analogs and use thereof
AssigneeVanderbilt University
InventorsGary A. Sulikowski, Christopher Fullenkamp, Kwangho Kim, Somnath Jana
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Abstract
Provided are 9-dechlorochrysophaentin analog compounds and the synthesis process thereof. The disclosed compound have remarkable antimicrobial activities that are comparable to, or even more potent than, the natural product chrysophaentin A. Also provided are method of inhibiting bacterial growth or treating bacterial infection by administering an effective amount of the disclosed compounds.
Claims20
A compound of formula (I), or a pharmaceutically acceptable salt thereof,
- wherein
- R1, R2, R3, R4, R5, and R6 are independently H, C1-4alkyl, C3-6cycloalkyl, —CH2C3-6cyclalkyl, —C(O)H, —C(O)C1-4alkyl, —C(O)C3-6cycloalkyl, or —C(O)CH2C3-6cyclalkyl;
- and
- Y is halogen and Z is H;
- or Y is H and Z is halogen.
2 more elements
Dependencies are inferred from the claim text.