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US 12,398,106 B2Granted
Catecholamine carbamate prodrugs for use in the treatment of parkinson's disease
AssigneeH. Lundbeck A/S
InventorsMorten Jørgensen, Erhad Ascic, Karin Sjödin, Klaus Gjervig Jensen, Jarkko Tapani Rautio
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Abstract
The present invention provides compounds of formula (Id) that are prodrugs of catecholamine for use in treatment of neurodegenerative diseases and disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson's disease.
Claims24
A compound according to formula (Ie)
- wherein Y is selected from H and a carbamoyl group of the formula (CONR1R2) with the formula below
- and wherein X is selected from H and a carbamoyl group of the formula (CONR3R4) with the formula below
- and
- wherein Y and X are not both H, and
- wherein R1, R2, R3 and R4 are each individually selected from the group consisting of H, C1-6 alkyl, an amino acid, an amino acid residue and a peptide;
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.