Analogues of pentamidine and uses therefor

A compound of Formula (A):

• or a pharmaceutically acceptable salt thereof, wherein:
• represents a single or double bond;
• m or n is independently an integer of 0, 1, 2 or 3;
• p is 0 or 1;
• Z1 or Z2 is independently O, S, SO2, NR3, or CR5R6;
• Y1-Y10 are each independently N or CR7, wherein at least one of Y1-Y10 is N, provided that when the moiety
• is taken together to form the moiety
• wherein one of Y1-Y5 is N and one of Y8-Y10 is N and the remaining Y1-Y10 are each CH, then Y1-Y5 are taken together with the amidine substituent to form an amidine substituted pyridine ring that is different than the amidine substituted pyridine ring formed by Y6-Y10 so that the compound is asymmetrical;
• R1 and R2 are each hydrogen,
• R3 is hydrogen, alkyl, cycloalkyl, aryl, or heteroaryl;
• R4 is hydrogen, halo, cycloalkyl, aryl, or heteroaryl;
• R5 or R6 is independently hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, amino,
• or R5 taken together with R6 forms a saturated or partially unsaturated 3-9 membered ring;
• and
• R7 is independently hydrogen, or halo.