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US 12,398,096 B2Granted
Method for preparing guanidino acetic acid
AssigneeEvonik Operations GmbH
InventorsTimo Stahl, Axel Ronneburg, Barbara Jäger, Philipp Roth
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Abstract
A method for preparing guanidino acetic acid involves reacting cyanamide and glycine in an aqueous reaction mixture in the presence of a base. The ammonia content in the reaction mixture is controlled to be below 20 g/L, and the dicyandiatrade content in the reaction mixture is kept below 5 wt.-%.
Claims16
A method for preparing guanidino acetic acid, the method comprising:
- reacting cyanamide and glycine in an aqueous reaction mixture in the presence of a base,
- wherein an ammonia content in the reaction mixture is controlled to be below 20 g/L, and wherein a dicyandiamide content in the reaction mixture is kept below 5 wt.-%, and
- wherein the dicyandiamide content is controlled by continuously adding the cyanamide and the glycine to the reaction mixture such that the molar ratio of glycine:
- cyanamide in the reaction mixture is 4:1 or higher, as long as the glycine is added to the reaction mixture.
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Dependencies are inferred from the claim text.