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US 12,397,173 B2Granted
Neutron capture therapy for infection control of surgical implants
AssigneeThe Curators of the University of Missouri
InventorsJohn Gahl, John Brockman, Michael Flagg, David A. Volgas, James Stannard, Charles Maitz
Life of this patent
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Abstract
The present invention provides an implant comprising an isotope capable of producing a dose of ionizing radiation upon exposure to a flux of low energy neutrons, and a method in which, after implantation, the implant is exposed to a flux of low energy neutrons to control or treat infections.
Claims18
A method for treating infection at an implantation site comprising:
- implanting a device comprising an isotope capable of producing a dose of ionizing radiation upon exposure to a flux of low energy neutrons into an human or animal subject, wherein the device is not a stent;
- and exposing said device to a flux of low energy neutrons to produce a dose of ionizing radiation suitable for treating bacterial infection at said implantation site;
- wherein the device comprises a body made of a material having a low neutron absorption cross-section and a surface layer of 1 μm to 100 μm thickness on the body, the isotope is selected from the group consisting of B-10, Li-6, Gd-157 and Dy-164 being disposed in the surface layer, such that the isotope is present at the surface of the device upon implantation.
Dependencies are inferred from the claim text.