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US 12,397,087 B2Granted
Embolic compositions and methods
AssigneeIncept, LLC
InventorsAmarpreet S. Sawhney, Hans Claesson, Raymond Lareau, Douglas Billings
Life of this patent
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Abstract
An embolization system and methods for controlling solidification of embolic compositions comprising a first and a second embolic component that react with each other in vivo at a target site to form an embolic material, with the embolic components being dilutable in physiological fluids so that they do not form an embolic composition at a site that is not desired.
Claims28
An embolization system for controlling solidification in vivo of an embolic composition, comprising
- a first fluid supply containing a first liquid,
- a second fluid supply containing a second liquid,
- a water soluble polymer that comprises at least two functional groups that comprise an unsaturated hydrocarbon group, wherein the water soluble polymer comprises a hydrophilic polymer with 2 to 4 arms extending from a core, each arm having a functional group capable of undergoing free radical polymerization, and the hydrophilic polymer having a molecular weight not less than 3000 Daltons between the functional groups,
- an initiator, and
- a co-initiator,
- with the initiator being disposed in one of the first liquid and the second liquid and the co-initiator being disposed in the other of the first liquid and the second liquid,
- with the water soluble polymer being disposed in at least one of the first liquid and the second liquid,
- wherein a mixture of the first liquid and the second liquid provides for reaction of the initiator and the co-initiator to form a radical initiator for a free radical polymerization of the functional groups to covalently crosslink the water soluble polymer to form an embolization material.
5 more elements
The embolization system of 1 wherein the co-initiator comprises Fe2+, Cr2+, V2+, Ti3+, Co2+, or Cu+ and wherein the initiator comprises a peroxide group, an alkyl hydrogen peroxide group, or a persulfate.
An embolization system comprising:
- a coaxial catheter comprising an inner catheter and an outer catheter,
- an adaptor,
- a first fluid supply containing a first liquid,
- a second fluid supply containing a second liquid,
- an initiator, and
- a co-initiator,
- with the initiator being disposed in one of the first liquid and the second liquid and the co-initiator being disposed in the other of the first liquid and the second liquid,
- a water soluble polymer disposed in at least one of the first liquid and the second liquid, wherein the water soluble polymer comprises at least two functional groups that comprise an unsaturated hydrocarbon group, wherein the water soluble polymer comprises a hydrophilic polymer with 2 to 4 arms extending from a core, each arm having a functional group capable of undergoing free radical polymerization, and the hydrophilic polymer having a molecular weight not less than 3000 Daltons between the functional groups,
- wherein a mixture of the first liquid and the second liquid provides for reaction of the initiator and the co-initiator to form a radical initiator for a free radical polymerization of the functional groups to covalently crosslink the water soluble polymer to form an embolization material, and
- wherein the inner catheter has an outer diameter ranging from 0.005 to 0.1 inches, the outer catheter has an inner diameter ranging from 0.01 to 0.2 inches, and the outer diameter of the inner catheter being selected to pass through the outer catheter, and
- wherein the adaptor is connectable to the inner catheter and the outer catheter.
8 more elements
An embolization system for controlling solidification in vivo of an embolic composition, comprising
- a first fluid supply containing a first liquid,
- a second fluid supply containing a second liquid,
- a water soluble polymer that comprises at least two functional groups that comprise an unsaturated hydrocarbon group, wherein the water soluble polymer comprises a hydrophilic polymer with 2 to 4 arms, each arm having a functional group, and the hydrophilic polymer having a molecular weight not less than 3000 Daltons between the functional groups,
- an initiator, and
- a co-initiator,
- with the initiator being disposed in one of the first liquid and the second liquid and the co-initiator being disposed in the other of the first liquid and the second liquid,
- with the water soluble polymer being disposed in at least one of the first liquid and the second liquid,
- wherein a mixture of the first liquid and the second liquid provides for reaction of the initiator and the co-initiator to form a radical initiator for a free radical polymerization of the functional groups to covalently crosslink the water soluble polymer to form an embolization material,
- wherein the water soluble polymer comprises polyethylene glycol diacrylate or a derivative thereof.
6 more elements
Dependencies are inferred from the claim text.