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US 12,397,046 B2Granted
Methods and compositions for treating and diagnosing autoimmune diseases
AssigneeNew York University
InventorGregg Silverman
Life of this patent
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Abstract
The application relates to methods for the diagnosis, treatment, and prevention of autoimmune and/or inflammatory disease such as systemic lupus erythematosus (SLE), lupus nephritis, IgA nephropathy, other types of glomerulonephritis.
Claims9
A method for determining (i) whether a subject has systemic lupus erythematosus (SLE) and/or lupus nephritis or (ii) whether a subject diagnosed with SLE or incomplete lupus (ILE) is at an increased risk for developing lupus nephritis, progression of SLE, and/or complications of lupus comprising:
- (a) determining in a gastrointestinal (GI) microbiota sample collected from the subject an abundance of bacteria from Ruminococcus gnavus strain CC55_001C, HM-1056 (Human Microbiome Project (HMP) ID 1201;
- GenBank:
- AZJF00000000);
- (b) comparing the abundance of bacteria determined in step (a) to a control abundance of said bacteria;
- and
- (c) determining that the subject has SLE and/or lupus nephritis or is at an increased risk for developing lupus nephritis, progression of SLE, and/or complications of lupus if the abundance of bacteria determined in step (a) is statistically significantly higher than the control abundance.
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Dependencies are inferred from the claim text.