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US 12,397,037 B2Granted
Methods and compositions for immunomodulation
AssigneeChildren's Medical Center Corporation
InventorsDavid M. Briscoe, Michael Klagsbrun, Sarah Bruneau, Nora Kochupurakkal, Hironao Nakayama
Life of this patent
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Abstract
The methods and uses described herein relate to the modulation of the immune system by modulation of Sema3F levels and/or activity, e.g. suppressing allograft rejection or inflammation by administering a Sema3F agonist or increasing an immune response by administering a Sema3F inhibitor.
Claims13
A method of reducing Akt/mTOR signaling in a subject in need of thereof, the method comprising administering a Semaphorin Family III Member F (Sema3F) polypeptide comprising a sequence having at least 95% identity to the sequence of SEQ ID NO:
- 1 or SEQ ID NO:5 to the subject.
Dependencies are inferred from the claim text.