US 12,397,027 B2 · Pseudorabies virus for treating tumors

Abstract

A pseudorabies virus (PRV) or a modified form thereof, or a genome sequence or a cDNA sequence containing the PRV or the modified form thereof, or nucleic acid molecules of a complementary sequence of the cDNA sequence, for treating tumors of subjects and/or reducing or inhibiting tumor recurrence, and for preparation of a pharmaceutical composition used for treating the tumors of the subjects and/or reducing or inhibiting the tumor recurrence. A method for treating tumors and/or reducing or inhibiting tumor recurrence, comprising a step of administering, on a subject having a need, the PRV or the modified form thereof, or nucleic acid molecules of the genome sequence containing the PRV or the modified form thereof.

Claims18

Dependent claims

A method for treating a tumor in a subject, the method comprising:

administering to a subject in need thereof, an effective amount of a modified pseudorabies virus (PRV), or a nucleic acid molecule;
wherein the nucleic acid molecule comprises a nucleotide sequence selected from the group consisting of:
(1) a genomic sequence or cDNA sequence of the modified PRV;
and
(2) a complementary sequence of the cDNA sequence, and
wherein the modified PRV does not express a functional EP0 protein compared to a wild-type PRV, and
wherein the tumor is selected from the group consisting of neuroglioma.

4 more elements

Dependencies are inferred from the claim text.

Pseudorabies virus for treating tumors

Life of this patent

Pseudorabies virus for treating tumors

Life of this patent

Abstract

Claims18