Method for facilitating maturation of the mammalian immune system
AssigneeInfinant Health, Inc.
InventorsDavid Kyle, Steven Frese, Samara Freeman-Sharkey, Bethany Henrick
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Abstract
The inventions described herein relate generally to the use of compositions to increase output of acetate and lactate while reducing pH and the levels of pathogenic bacteria and inflammation in the gut of a nursing infant mammal including humans. These compositions generally comprise one or more bacterial strains selected for their growth on mammalian milk oligosaccharides, a source of mammalian milk oligosaccharides, and, optionally, nutritive components required for the growth of that infant mammal.
Claims19
A method of controlling the intestinal environment of a mammal by increasing and/or maintaining a level of short chain fatty acids (SCFA) or organic acids in the mammal's colon, the method comprising:
- a) selecting a dysbiotic mammal having a lactate:acetate ratio of less than 2:3 in its feces;
- and
- b) administering to the mammal a bacterial composition comprising bacteria capable of colonization of the mammal's colon;
- and
- c) adding one or more mammalian milk oligosaccharides (MMO) to the mammal's diet as necessary to maintain MMO as at least 10% of total dietary fiber in the mammal's diet.
Dependencies are inferred from the claim text.