Determination of antidepressants by mass spectrometry
AssigneeQuest Diagnostics Investments Incorporated
InventorsAnita Dermartirosian, Edith Shahbol, Karin Thomassian, Shaun Rezaei, Asad Shah
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Abstract
A method for detecting or determining an amount of one or more serotonin and norepinephrine reuptake inhibitors (SNRI) and SNRI metabolites in a sample by tandem mass spectrometry includes subjecting the sample to ionization under conditions suitable to produce one or more ions detectable by mass spectrometry; determining the amount of one or more ions by tandem mass spectrometry; and determining the amount of SNRI and SNRI metabolites in the sample based upon the amount of the one or more ions determined by tandem mass spectrometry; and wherein the one or more SNRI and SNRI metabolites includes duloxetine.
Claims16
A method for simultaneously detecting or determining an amount of duloxetine, fluoxetine, and norfluoxetine in a biological sample by tandem mass spectrometry, the method comprising:
- subjecting a biological sample to ionization under conditions suitable to produce one or more ions detectable by mass spectrometry;
- determining the amount of one or more ions by tandem mass spectrometry, wherein the one or more ions comprise a norfluoxetine fragment ion with a mass-to-charge (m/z) ratio of 30.1±0.2;
- and
- using the amount of the one or more ions to determine the amount of duloxetine, fluoxetine, and norfluoxetine in the biological sample.
A method for detecting or determining an amount of norfluoxetine in a biological sample by tandem mass spectrometry, the method comprising:
- subjecting a biological sample to ionization under conditions suitable to produce a norfluoxetine fragment ion with a mass-to-charge (m/z) ratio of 30.1±0.2;
- determining an amount of the norfluoxetine fragment ion by tandem mass spectrometry;
- and
- determining the amount of norfluoxetine in the biological sample, wherein the amount of norfluoxetine is related to the amount of the norfluoxetine fragment ion.
Dependencies are inferred from the claim text.