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US 12,392,772 B2Granted
Method for detection and separation of enantiomers using vesicle-like nanostructures self-assembled from Janus nanoparticles
AssigneeThe Regents of the University of California
InventorsShaowei Chen, Jia-En Lu
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Abstract
A method for processing an analyte includes: adding a plurality of amphiphilic nanoparticles to a solvent to form a mixture having a plurality of enantioselective nanoparticle ensembles; adding an analyte to the mixture; obtaining a test circular dichroism spectrum of the mixture with the analyte; and determining an enantiomeric property of the analyte based on a comparison of a baseline circular dichroism spectrum of the analyte mixture to the test circular dichroism spectrum.
Claims14
A method for processing an analyte, the method comprising:
- adding a plurality of amphiphilic nanoparticles to a solvent to form a mixture, wherein each amphiphilic nanoparticle of the plurality of amphiphilic nanoparticles includes a gold core having a first surface portion and a second surface portion, the first surface portion functionalized with 1-hexanethiolate and the second surface portion functionalized 3-mercapto-1,2-propanediol via interfacial ligand exchange reaction and the plurality of amphiphilic nanoparticles self-assemble into a plurality of enantioselective, vesicle-like nanostructures without assistance of a template or a scaffold;
- adding an analyte to the mixture to form an analyte mixture, wherein molecules of the analyte bind with the plurality of enantioselective, vesicle-like nanostructures;
- obtaining a test circular dichroism spectrum of the analyte mixture;
- and
- determining an enantiomeric property of the analyte based on a comparison of a baseline circular dichroism spectrum of the mixture to the test circular dichroism spectrum of the analyte mixture.
2 more elements
A kit for processing an analyte, the kit comprising:
- a first reagent including a plurality of amphiphilic nanoparticles, each of the plurality of amphiphilic nanoparticles includes a gold core having a first surface portion and a second surface portion, the first surface portion functionalized with 1-hexanethiolate and the second surface portion functionalized 3-mercapto-1,2-propanediol via interfacial ligand exchange reaction;
- and
- a second reagent including a polar solvent, wherein upon adding the first reagent to the second reagent to form a mixture, the plurality of amphiphilic nanoparticles self-assemble into a plurality of enantioselective, vesicle-like nanostructures without assistance of a template or a scaffold, wherein the plurality of enantioselective, vesicle-like nanostructures are configured to bind with analyte molecules.
Dependencies are inferred from the claim text.