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US 12,391,979 B2Granted
Spatially encoded biological assays
AssigneePrognosys Biosciences, Inc.
InventorMark S. Chee
Life of this patent
Estimating the term…
Abstract
The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.
Claims20
A system comprising:
- an imaging apparatus configured to obtain an image of a tissue section on a substrate comprising encoded probes, wherein the encoded probes comprise coding tags and nucleic acid sequences that interact with target biological molecules;
- a microcircuit arrangement configured to obtain information about the tissue section based on the obtained image;
- a substrate holder comprising an open gasket configured to receive a reagent into the open gasket, and wherein the tissue section is disposed on the substrate within the open gasket.
Dependencies are inferred from the claim text.