Magnetic inorganic iron-based nanoparticles
AssigneeBar-Ilan University
InventorsJean-Paul Lellouche, Shulamit Michaeli, Limor Liron Israel, Emmanuel Lellouche, Yekaterina Kapilov-Buchman
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Abstract
A nanoparticle, which has a metal oxide core and a cerium shell is provided. The weight ratio of the cerium within the shell to the metal oxide in the core is at least 1%. Additionally a method for delivering a ligand into a cell with the nanoparticle is provided. Processes for making the nanoparticle which include: sonicating an aqueous composition containing Ceric Ammonium Nitrate and a prefabricated nano particle suspension; and (b) adding a polycationic polymer to the mixture (for NP surface functionalization), are also described.
Claims13
A method for delivering a ligand into a cell, comprising the step of contacting said cell with a nanoparticle, comprising cerium, a core, and an ultrasound-deposited polyCOOH organic shell, wherein said core comprises maghemite (gamma-Fe2O3), wherein the weight ratio of said cerium to said maghemite is at least 2%, said shell is a single layer and is characterized by orthogonal surface multifunctionality, said shell comprises at least one ligand being bound to said cerium within said shell, thereby delivering a ligand into a cell.
Dependencies are inferred from the claim text.