SIRPα-silenced natural killer (NK) cells
AssigneeThe Regents of the University of California
InventorTobias Deuse
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Abstract
The invention provides Natural Killer (NK) cells that have a reduced or ablated Signal Regulatory Protein Alpha (SIRPα−) function when compared to a NK cell having an unmodified SIRPα− function that effectively kills a population of cancer cells that express CD47.
Claims22
A population of modified Natural Killer (NK) cells, comprising a reduced Signal Regulatory Protein Alpha (SIRPα) function when compared to an NK cell population having an unmodified SIRPα function, wherein said modified NK cells effectively kill a population of cancer cells that express CD47 in an in vitro NK assay.
A population of modified Natural Killer (NK) cells, comprising a reduced Signal Regulatory Protein Alpha (SIRPα) function when compared to a NK cell having an unmodified SIRPα function, wherein said modified NK cells effectively kill a population of hypoimmune cells that express CD47 in an in vitro NK assay.
Dependencies are inferred from the claim text.