Peptoid polymers and methods of use
AssigneeX-Therma, Inc.
InventorXiaoxi Wei
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Abstract
The present invention provides peptoid polymers and salts thereof that comprise hydrophobic and polar peptoid monomers and are capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids and salts thereof comprising the peptoid polymers provided herein. The peptoid polymers, peptoid-peptide hybrids, and salts thereof provided herein are useful for making cryoprotectant solutions. The peptoid polymers, peptoid-peptide hybrids, salts thereof, and cryoprotectant solutions provided herein are useful for making antifreeze solutions, frozen food products, and cosmetic care products. Also provided herein are methods for preserving a tissue, an organ, a cell, or a biological macromolecule using the compositions described herein.
Claims13
A peptoid polymer or salt thereof having the sequence [H2P2]n, [P2H2]n, X-[H2P2]n-Y, X-[P2H2]n-Y, [H2P2]nH2, [P2H2]nH2, [H2P2]nP2, or [P2H2]nP2,
- wherein the subscript n is between 2 and 5;
- wherein H is a hydrophobic peptoid monomer selected from the group consisting of
- wherein the subscript m is the number of repeat units and is between 1 and 10,
- wherein P is a polar peptoid monomer selected from the group consisting of
- and
- wherein X and Y are independently selected from the group consisting of H, optionally substituted C1-8 alkyl, optionally substituted C1-8 acyl, optionally substituted C1-8 alkylamino,-OH,-SH,-NH2, secondary amine, tertiary amine, carboxy, optionally substituted C1-8 hydroxyalkyl, optionally substituted C1-8 alkylamino, optionally substituted C2-8 alkylthio, optionally substituted C1-8 carboxyalkyl, and halogen.
Dependencies are inferred from the claim text.