HPV proteins, antibodies, and uses in managing abnormal epithelial cell growth
AssigneeEmory University
InventorsAndreas Wieland, Rafi Ahmed
Life of this patent
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Abstract
This disclosure relates to HPV proteins, antibodies, and uses in managing abnormal epithelial cell growth. In certain embodiments, this disclosure relates to detecting an HPV protein in a sample and correlating the presence as an indication that a subject is at risk of developing an HPV-related disease or condition. In certain embodiments, the HPV protein is E2 and/or E6. In certain embodiments, this disclosure relates to vaccinating or treating a subject for an HPV infection or related condition optionally in combination with immune-checkpoint inhibitors. In certain embodiments, this disclosure relates to HPV protein specific antibodies and binding agents for uses reported herein.
Claims12
A chimeric antibody that specifically binds HPV16 E2 protein wherein the antibody comprises a light chain and a heavy chain,
- wherein the light chain CDR1 is GYTFTSYP (SEQ ID NO:
- 67), CDR2 is INTNNGNP (SEQ ID NO:
- 68), and CDR3 is ARAGFEIYGDAFTYYGMDV (SEQ ID NO:
- 69);
- and
- wherein the heavy chain CDR1 is TGDIGAYKF (SEQ ID NO:
- 72), CDR2 is EVSN (SEQ ID NO:
- 73), and CDR3 is SSYRGNTTL (SEQ ID NO:
- 74).
A chimeric antibody that specifically binds HPV16 E2 protein wherein the antibody comprises a light chain and a heavy chain,
- wherein the light chain CDR1 is SGRTTFA (SEQ ID NO:
- 62), CDR2 is IYNDGSH (SEQ ID NO:
- 63), and CDR3 is QTWGSGSVM (SEQ ID NO:
- 64);
- and
- wherein the heavy chain CDR1 is GFTFTNYA (SEQ ID NO:
- 57), CDR2 is ITDNADAT (SEQ ID NO:
- 58), and CDR3 is AKHHHRDDAFDV (SEQ ID NO:
- 59).
A chimeric antibody that specifically binds HPV16 E2 protein wherein the antibody comprises a light chain and a heavy chain,
- wherein the light chain CDR1 is VLPKKY (SEQ ID NO:
- 176), CDR2 is EDTK (SEQ ID NO:
- 177), and CDR3 is YSTDSSGNF (SEQ ID NO:
- 178);
- and
- wherein the heavy chain CDR1 is GYDFAKYY (SEQ ID NO:
- 134), CDR2 is INPQNGVT (SEQ ID NO:
- 135), and CDR3 is NILYISGSNVWDY (SEQ ID NO:
- 136).
Dependencies are inferred from the claim text.