Polypeptide having effect of inhibiting proliferation of leukemia cells
OwnerJiang Zhu, An Zhong +1inventors
InventorsJiang Zhu, An Zhong, Meiqi Lv
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Abstract
The present disclosure discloses a polypeptide having an effect of inhibiting the proliferation of leukemia cells, and particularly relates to use of the polypeptide in a drug for treating leukemia. The polypeptide consists of 37 amino acids, with the amino acid sequence thereof being Lys-Glu-Ser-Met-Asp-Ala-Asn-Lys-Pro-Thr-Lys-Asn-Leu-Pro-Leu-Lys-Lys-Ile-Pro-Cys-Lys-Thr-Ser-Ala-Pro-Ser-Gln-Ser-Phe-Phe-Ala-Arg-Asp-Asn-Thr-Ala-Asn, and the N-terminus of the polypeptide being conjugated with myristate. The polypeptide prepared by the present disclosure can enter the leukemia cells by conjugating with the myristic acid, thereby achieving the effect of inhibiting the proliferation of the leukemic cells.
Claims2
A polypeptide having an effect of inhibiting the proliferation of leukemia cells, wherein the polypeptide consists of 37 amino acids, with the amino acid sequence of
- SEQ ID NO:
- 1
- Lys-Glu-Ser-Met-Asp-Ala-Asn-Lys-Pro-Thr-Lys-Asn-
- Leu-Pro-Leu-Lys-Lys-Ile-Pro-Cys-Lys-Thr-Ser-Ala-
- Pro-Ser-Gln-Ser-Phe-Phe-Ala-Arg-Asp-Asn-Thr-Ala-
- Asn.
Dependencies are inferred from the claim text.