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US 12,391,691 B2Granted
Synthesis of key intermediate of KRAS G12C inhibitor compound
AssigneeAmgen Inc.
InventorsAndrew Thomas Parsons, Brian McNeil Cochran, William Powazinik, IV, Marc Anthony Caporini
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Abstract
The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure useful for the synthesis of compounds that target KRAS G12C mutations, such as
Claims14
A process for preparing a composition of Formula (4a):
- comprising reacting a compound of Formula (4)
- with a compound of Formula (B1)
- in the presence of 2-methyltetrahydrofuran to form the composition of Formula (4a).
A process for preparing a compound of Formula (5M):
- the process comprising:
- a) reacting Compound (4):
- with Compound (B1):
- in the presence of 2-methyltetrahydrofuran to form a composition of Formula (4a):
- as crystals;
- b) isolating the composition of Formula (4a);
- and
- c) treating the isolated composition Formula (4a) with a base to produce the compound of Formula (5M).
5 more elements
Dependencies are inferred from the claim text.