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US 12,391,662 B2Granted
Lipid compounds and lipid nanoparticle compositions
AssigneesRinuagene Biotechnology Co., Ltd., Rinuagene International Hk Limited
InventorsShan Cen, Kai Lv, Zhenlei Yu, Yijie Dong
Life of this patent
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Abstract
The present application disclosed a compound of formula (I) and a salt and a stereoisomer thereof, wherein each variable is as defined in the specification. The present application also disclosed a nanoparticle composition comprising the compound or a salt or a stereoisomer thereof, and the use of the nanoparticle composition for delivering active agents.
Claims20
A compound of formula (I), or a salt or a stereoisomer thereof,
- wherein
- R1 is
- R1a and R1b are each independently —CH3;
- R2 and R3 are each independently H;
- R4 is C10, C11 or C12 linear alkyl;
- R5 and R6 are identical and are selected from C6, C7 and C8 linear alkyl;
- X and Y are each independently O;
- X1 and X2 are independently selected from C═O and O, Y1 and Y2 are independently selected from C═O and O, with the proviso that X1 and Y1 are not both C═O or O, and X2 and Y2 are not both C═O or O;
- m is 0, and n is 1;
- o is 5 or 6;
- p is 7 or 8, and
- q is 2, 3 or 4.
9 more elements
A compound, or a salt or a stereoisomer thereof, wherein the compound is selected from
Dependencies are inferred from the claim text.