Heteroaromatic acetamide derivative, and preparation and use thereof

A heteroaromatic acetamide derivative, characterized in that the derivative is a compound selected from the following compounds:

• 4-((1-(4-(4-(trifluoromethyl)phenyl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(3-(trifluoromethyl)phenyl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(2-(trifluoromethyl)phenyl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(2-(trifluoromethoxy)phenyl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(4-(trifluoromethoxy)phenyl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(4-chloro-2-methoxyphenyl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(3-methyl)phenyl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(6-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(6-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)cyclopropyl)amino)benzonitrile;
• 4-((1-(4-(6-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)cyclobutyl)amino)benzonitrile;
• 4-((3,3-dimethyl-1-oxo-1-(4-(6-trifluoromethyl)pyridin-2-yl)piperazine-1-yl)butan-2-yl)amino)benzonitrile;
• 4-((1-(4-(6-methylpyridin-2-yl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 6-(4-(1-((4-cyanophenyl)amino)cyclopentane-1-carbonyl)piperazine-1-yl)N,N-dimethylnicotinamide;
• 4-((1-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(4-(trifluoromethyl)pyrimidin-2-yl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(6-(trifluoromethyl)pyridazin-3-yl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(6-(trifluoromethyl)pyridazin-3-yl)piperazine-1-carbonyl)cyclopentyl)amino)chlorobenzene;
• 4-((1-(4-(6-(trifluoromethyl)pyridazin-3-yl)piperazine-1-carbonyl)cyclopentyl)amino)nitrobenzene;
• 2-chloro-4-((1-(4-(6-(trifluoromethyl)pyridazin-3-yl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 2-chloro-4-((1-(4-(6-(trifluoromethyl)pyridazin-3-yl)piperazine-1-carbonyl)phenyl)amino)benzonitrile;
• 4-((1-(4-(5-(trifluoromethyl)thien-2-yl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(5-(trifluoromethyl)thiazol-2-yl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(1-methyl-1H-pyrazol-3-yl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(6-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)cyclopentyl)amino)phenylacetylene;
• 4-((1-(4-(cyclopentanemethyl)piperazine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(tert-butyl)piperidine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(isobutyl)piperidine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(cyclopentyl)piperidine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(8-aza-spiro [4.5]decane-8-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(cyclohexyl)piperidine-1-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(4-(tert-butyl)piperidine-1-carbonyl)cyclopentyl)amino)phenylacetylene;
• 4-((1-(4-(tert-butyl)piperidine-1-carbonyl)cyclobutyl)amino)benzonitrile;
• 4-((1-(4-(tert-butyl)piperidine-1-carbonyl)cyclopropyl)amino)benzonitrile;
• 2-((1-(4-(tert-butyl)piperidine-1-carbonyl)cyclopentyl)amino) thiazole-4-carbonitrile;
• 2-((1-(4-(tert-butyl)piperidine-1-carbonyl)cyclopentyl)amino) thiazole-5-carbonitrile;
• 2-((1-(4-(tert-butyl)piperidine-1-carbonyl)cyclopentyl)amino) oxazole-4-carbonitrile;
• 4-((1-(4-(tert-butyl)piperidine-1-carbonyl)cyclopentyl)amino)-1-methyl-1H-imidazole-2-carbonitrile;
• 4-((1-(4-(tert-butyl)piperidine-1-carbonyl)tert-butyl)amino)benzonitrile;
• 4-((1-(4-(tert-butyl)piperidine-1-carbonyl)cyclopentyl)methylamino)benzonitrile;
• 4-((1-(4-(tert-butyl)piperidine-1-carbonyl)cyclopentyl)methylamino)trifluoromethylbenzene;
• 4-((1-(4-(tert-butyl)piperidine-1-carbonyl)cyclopentyl)amino)chlorobenzene;
• 4-((1-(4-(6-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)cyclopentyl)oxy)benzonitrile;
• 4-((1-(4-(m-methylphenyl)piperazine-1-carbonyl)cyclopentyl)oxy)benzonitrile;
• 4-((1-(4-(trifluoromethyl)phenyl)piperazine-1-carbonyl)cyclopentyl)oxy)benzonitrile;
• 4-((1-(4-(4-(trifluoromethyl)pyrimidin-2-yl)piperazine-1-carbonyl)cyclopentyl)oxy)benzonitrile;
• 4-((1-(4-(4-(trifluoromethyl)pyrimidin-2-yl)piperazine-1-carbonyl)tert-butyl)oxy)benzonitrile;
• 4-((1-(4-(6-(trifluoromethyl)pyridazin-3-yl)piperazine-1-carbonyl)cyclopentyl)oxy)benzonitrile;
• 4-((1-(4-(6-(trifluoromethyl)pyridazin-3-yl)piperazine-1-carbonyl)cyclopentyl)oxy)nitrobenzene;
• 4-((1-(4-(tert-butyl)piperidine-1-carbonyl)cyclopentyl)oxy)benzonitrile;
• 4-((1-(4-(tert-butyl)piperazine-1-carbonyl)cyclopentyl)oxy)benzonitrile;
• 4-((1-(4-(6-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)cyclobutyl)oxy)benzonitrile;
• 4-((1-(4-(4-(trifluoromethyl)pyrimidin-2-yl)piperazine-1-carbonyl)cyclopentyl)oxy)oxazole-4-carbonitrile;
• 2-chloro-4-((1-(4-(6-(trifluoromethyl)pyridazin-3-yl)piperazine-1-carbonyl)cyclopentyl)oxy)benzonitrile;
• 1-methyl-4-((1-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)cyclopentyl)oxy)-1H-imidazole-2-carbonitrile;
• 2-((1-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)cyclopentyl)oxy)thiazole-5-carbonitrile;
• 4-(1-phenyl-2-(4-6-(trifluoromethyl)pyridazin-3-yl)piperazine-1-yl)ethoxy)benzonitrile;
• 4-((1-(4-(tert-butyl)piperazine-1-carbonyl)cyclopentyl)oxy)trifluoromethylbenzene;
• 5-((1-(4-(tert-butyl)piperidine-1-carbonyl)cyclopentyl)oxy)-1-methyl-1H-pyrrole-3-carbonitrile;
• 4-((1-(4-(tert-butyl)piperazine-1-carbonyl)cyclopentyl)sulfanyl)benzonitrile;
• 5-((1-(4-(tert-butyl)piperidine-1-carbonyl)cyclopentyl)sulfanyl)-1-methyl-1H-indole;
• 4-((1-(8-(6-(trifluoromethyl)pyridin-2-yl)-3,8-diazabicyclo [3.2.1] octane-3-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(5-(6-(trifluoromethyl)pyridin-2-yl)-2,5-diazabicyclo [2.2.2] octane-2-carbonyl)cyclopentyl)amino)benzonitrile;
• 4-((1-(8-(6-(trifluoromethyl)pyridin-2-yl)-3,8-diazabicyclo [3.2.1] octane-3-carbonyl)cyclopentyl)amino)benzonitrile;
• and
• 4-((1-(5-(6-(trifluoromethyl)pyridin-2-yl)-2,5-diazabicyclo [2.2.2] octane-2-carbonyl)cyclopentyl)oxy)benzonitrile or a pharmaceutically acceptable salt thereof.