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US 12,391,657 B2Granted
Small molecules that bind and/or modulate differentforms of tau oligomers
AssigneesBoard of Regents, The University of Texas System, University of Palermo
InventorsRakez Kayed, Filippa Lo Cascio, Antonio Palumbo Piccionello, Andrea Pace
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Abstract
The present invention relates to novel small molecules of Formulas I, II, III, Ilia, Illb, and IV and pharmaceutically acceptable salts thereof, as well as the preparation and the use thereof.
Claims4
A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein:
- R is OH, alkoxy, alkyl, dialkylamino, or —O-alcohol protecting group selected from OMOM or OBn;
- R′ is hydrogen, halogen, or alkoxy;
- and
- X is CO—R1 or COCH2Y;
- wherein Y is chosen from halogen, OH, OR1, NH2, NHR1, NR1R2, SH, and SR1;
- R1 and R2 are independently C1-C10-alkyl;
- and
- wherein each phenyl vinyl double bond moiety bond geometry is independently E or Z configuration.
5 more elements
Dependencies are inferred from the claim text.