CFTR regulators and methods of use thereof

A compound of formula (IB), (IC), (ID), or (IE):

• wherein:
• R2 is hydrogen, —CX32.1, —CHX22.1, —(CH2)n2CX32.1, —OR2A, substituted alkyl, unsubstituted alkyl, substituted heteroalkyl, unsubstituted heteroalkyl, substituted cycloalkyl, unsubstituted cycloalkyl, substituted heterocycloalkyl, unsubstituted heterocycloalkyl, substituted aryl, unsubstituted aryl, substituted heteroaryl, or unsubstituted heteroaryl;
• R3 is hydrogen, —C(O)R3D, —C(O)NHNR3BR3C, —C(O)OR3D, —SO2R3A, C(O)NR3BR3C, substituted alkyl, unsubstituted alkyl, substituted heteroalkyl, unsubstituted heteroalkyl, substituted cycloalkyl, unsubstituted cycloalkyl, substituted heterocycloalkyl, unsubstituted heterocycloalkyl, substituted aryl, unsubstituted aryl, substituted heteroaryl, or unsubstituted heteroaryl;
• R4 is hydrogen, —C(O)R4D, —C(O)NHNR4BR4C, —C(O)OR4D, —SO2R44, —C(O)NR4BR4C, substituted alkyl, unsubstituted alkyl, substituted heteroalkyl, unsubstituted heteroalkyl, substituted cycloalkyl\, unsubstituted cycloalkyl, substituted heterocycloalkyl, unsubstituted heterocycloalkyl, substituted aryl, unsubstituted aryl, substituted heteroaryl, or unsubstituted heteroaryl;
• or R3 and R4 are joined to form, together with the atoms to which they are attached, a substituted heterocycloalkyl, unsubstituted heterocycloalkyl, substituted heteroaryl, or unsubstituted heteroaryl;
• R5 is hydrogen, —C(O)R5D, —C(O)NHNR5BR5C, —C(O)OR5D, —SO2R5A, C(O)NR5BR5C, substituted alkyl, unsubstituted alkyl, substituted heteroalkyl, unsubstituted heteroalkyl, substituted cycloalkyl, unsubstituted cycloalkyl, substituted heterocycloalkyl, unsubstituted heterocycloalkyl, substituted aryl, unsubstituted aryl, substituted heteroaryl, or unsubstituted heteroaryl;
• R7 is hydrogen, halogen, —CX37.1, —CHX27.1, —CH2X7.1, CN, —SOn7R7A, —SOv7NR7BR7C, —NHNR7BR7C, —ONR7BR7C, —NHC(O)NHNR7BR7C, —NHC(O)NR7BR7C, —N(O)m7, —NR7BR7C, —C(O)R7D, —C(O)OR7, —C(O)NR7BR7C, —OR7A, —NR7BSO2R7A,—NR7AC(O)R7C, —NR7BC(O)OR7D, —NR7BOR7D, —OCX37.1, —OCHX27.1, substituted alkyl, unsubstituted alkyl, substituted heteroalkyl, unsubstituted heteroalkyl, substituted cycloalkyl, unsubstituted cycloalkyl, substituted heterocycloalkyl, unsubstituted heterocycloalkyl, substituted aryl, unsubstituted aryl, or substituted heteroaryl, or unsubstituted heteroaryl;
• R8 is hydrogen, halogen, —CX38.1, —CHX28.1, —CH2X8.1, CN, —SOn8R8A, —SOv8 NR8BR8C, —NHNR8BR8C, —ONR8BR8C, —NHC(O)NHNR8BR8C, —NHC(O)NR8BR8C, —N(O)m8, —NR8BR8C, —C(O)R8D, —C(O)OR8D, —C(O)NR8BR8C, —OR8A, —NR8BSO2R8A, —NR8BC(O)R8D, —NR8BC(O)OR8D, —NR8BOR8D, —OCX38.1, —OCHX28.1, substituted alkyl, unsubstituted alkyl, substituted heteroalkyl, unsubstituted heteroalkyl, substituted cycloalkyl, unsubstituted cycloalkyl, substituted heterocycloalkyl, unsubstituted heterocycloalkyl, substituted aryl, unsubstituted aryl, substituted heteroaryl, or unsubstituted heteroaryl;
• R9 is hydrogen, halogen, —CX39.1, —CHX29.1, —CH2X9.1, CN, —SOn9R9A, —SOv9 NR9BR9C, —NHNR9BR9C, —ONR9BR9C, —NHC(O)NHNR9BR9C, —NHC(O)NR9BR9C, —N(O)m9, —NR9BR9C, —C(O)ROD, —C(O)OR9D, —C(O)NR9BR9C, —OR9A, —NR9BSO2R9A, —NR9BC(O)R9D, —NR9BC(O)OR9D, —NR9BOR9D, —OCX39.1, —OCHX29.1, substituted alkyl, unsubstituted alkyl, substituted heteroalkyl, unsubstituted heteroalkyl, substituted cycloalkyl, unsubstituted cycloalkyl, substituted heterocycloalkyl, unsubstituted heterocycloalkyl, substituted aryl, unsubstituted aryl, substituted heteroaryl, or unsubstituted heteroaryl;
• or R8 and R9 are optionally joined to form, together with the atoms to which they are attached, substituted cycloalkyl, unsubstituted cycloalkyl, substituted heterocycloalkyl, unsubstituted heterocycloalkyl, substituted aryl, unsubstituted aryl, substituted heteroaryl, or unsubstituted heteroaryl;
• R10 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2A, R3A, R3B, R3C, R3D, R4A, R4B, R4C, R4D, R5A, R5B, R5C, R5D, R7A, R7B, R7C, R7D, R8A, R8B, R8C, R8D, R9A, R9B, R9C, and R9D are, independently, hydrogen, halogen, CF3, CCl3, CBr3, Cl3, OH, NH2, COOH, CONH2, NO2, SH, SO3H, SO4H, SO2NH2, NHNH2, ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, OCF3, OCCl3, OCBr3, OCl3, OCHF2, OCHCl2, OCHBr2, OCHI2, substituted alkyl, unsubstituted alkyl, substituted heteroalkyl, unsubstituted heteroalkyl, substituted cycloalkyl, unsubstituted cycloalkyl, substituted heterocycloalkyl, unsubstituted heterocycloalkyl, substituted aryl, unsubstituted aryl, substituted heteroaryl, or unsubstituted heteroaryl;
• or R3B, R3C, R4B, R4C, R5B, R5C, R7B, R7C, R8B, R8C, R9B and R9C bonded to the same nitrogen atom are joined to form, together with the atoms to which they are attached, a substituted heterocycloalkyl, unsubstituted heterocycloalkyl, substituted heteroaryl, or unsubstituted heteroaryl;
• X2.1, X7.1, X8.1, and X9.1 are independently C1, Br, I or F;
• n2, n7, n8, and n9 are, independently, 0 to 4;
• and
• m7, m8, m9, v7, v8, and v9 are, independently, 1 or 2;
• or a pharmaceutically acceptable salt thereof.