Benzamide compound and preparation method, use, and pharmaceutical composition thereof
AssigneeInstitute of Materia Medica, Chinese Academy of Medical Sciences
InventorsHeng Xu, Xiaoguang Chen, Songwen Lin, Ming Ji, Nina Xue, Deyu Wu, Jing Jin
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Abstract
The present invention relates to a benzamide compound and a preparation method, use and pharmaceutical composition thereof. The benzamide compound represented by formula (I) is a STAT3 inhibitor, and can be used to prevent and/or treat a disease related to STAT3 activity, such as a tumor, autoimmune disease, renal disease, cardiovascular disease, inflammation, metabolic/endocrine dysfunction, and neurological disease.
Claims19
A compound represented by Formula (I), or a stereoisomer, a geometric isomer, a tautomer or a pharmaceutically acceptable salt thereof:
- wherein,
- R1 is selected from hydrogen, cyano, difluoromethyl, trifluoromethyl, halogen, C1-3 alkyl, C1-3 alkoxy;
- R2 is selected from 6- to 10-membered aryl or 5- to 10-membered heteroaryl;
- wherein the 6- to 10-membered aryl or 5- to 10-membered heteroaryl is optionally substituted by (Ra)m;
- or the 6- to 10-membered aryl or 5- to 10-membered heteroaryl is phenyl fused to 4- to 6-membered cycloalkene or 4- to 6-membered heterocycloalkene or 5- to 6-membered heteroaryl fused to the same;
- each Ra is independently selected from the following groups:
- cyano, difluoromethyl, trifluoromethyl, halogen, C1-3 alkyl, C3-7 cycloalkyl, C1-3 alkoxy;
- m is 0, 1, 2, 3, 4 or 5;
- R3, R4, R5, R6 are each independently selected from hydrogen, cyano, difluoromethyl, trifluoromethyl, halogen, C1-3 alkyl, C1-3 alkoxy.
Dependencies are inferred from the claim text.