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US 12,391,641 B2Granted
Prostaglandin EP4 receptor antagonist compounds
AssigneeNxera Pharma UK Limitied
InventorsMiles Stuart Congreve, Nigel Alan Swain, Benjamin Whitehurst
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Abstract
The disclosures herein relate to novel compounds of formula (1): (1) and salts thereof, wherein A, X, R1, R2, R3, R4, R10 and R11 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with EP4 receptors.
Claims27
A compound of Formula (1):
- or a salt thereof, wherein;
- A is selected from the group consisting of:
- X is an optionally substituted phenyl ring, an optionally substituted pyridyl ring or an optionally substituted imidazopyridine ring system;
- R1 and R2 are independently H or a C1-3 alkyl group which is optionally substituted with one or more fluorine atoms;
- or R1 and R2 are joined to form a 3-6 membered carbocyclic ring which is optionally substituted with one or more fluorine atoms;
- R3 is H, C1-3 alkyl or F;
- R4 is H or C1-3 alkyl;
- R8 is C1-3 alkyl or a C3-6 cycloalkyl ring;
- and either R10 and R11 are both methyl or R10 and R11 are joined to form a cyclobutyl ring.
6 more elements
A compound which is selected from the group consisting of:
- or a salt thereof.
A compound which is selected from the group consisting of:
- or a salt thereof.
Dependencies are inferred from the claim text.