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US 12,390,534 B2Granted
Branched degradable polyethylene glycol binder
AssigneesNof Corporation, Tokyo Institute of Technology
InventorsHiroki Yoshioka, Kazuki Osakama, Mika Hamura, Takanori Inaba, Nobuhiro Nishiyama, Makoto Matsui, Hiroyasu Takemoto, Takahiro Nomoto, Xiaohang Sun
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Abstract
A bio-related substance bonded to a branched and degradable polyethylene glycol derivative that is degraded in the cells represented by the following formula (A): wherein each symbol is as defined in the present specification, is provided by the present invention.
Claims12
A degradable polyethylene glycol derivative-bonded bio-related substance of formula (2), formula (3), or formula (4):
- wherein
- D is a bio-related substance;
- Glu is a glutamic acid residue;
- Z is a degradable oligopeptide selected from the group consisting of glycine-phenylalanine-leucine-glycine (SEQ ID NO:
- 4), glycine-glycine-phenylalanine-glycine (SEQ ID NO:
- 5), glycine-phenylalanine-glycine, glycine-leucine-glycine, valine-citrulline-glycine, valine-alanine-glycine, and phenylalanine-glycine;
- L1 and L2 are each independently a divalent spacer;
- and
- n is 220-460.
6 more elements
Dependencies are inferred from the claim text.