Influenza b virus mutants and uses therefor
AssigneeFluGen, Inc.
InventorsMichael J. Moser, Yasuko Hatta, Pamuk Bilsel
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Abstract
Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant BM2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination.
Claims7
A recombinant influenza A virus comprising a mutant BM2 protein encoded by a sequence selected from the group consisting of SEQ ID NO:
- 27, SEQ ID NO:
- 28, SEQ ID NO:
- 29, SEQ ID NO:
- 30, SEQ ID NO:
- 31, and SEQ ID NO:
- 32.
A host cell for propagating a recombinant influenza virus, wherein the host cell is a Vero cell expressing a sequence selected from the group consisting of SEQ ID NO:
- 27, SEQ ID NO:
- 28, SEQ ID NO:
- 29, SEQ ID NO:
- 30, SEQ ID NO:
- 31, and SEQ ID NO:
- 32.
Dependencies are inferred from the claim text.