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US 12,390,499 B2Granted
Bacteriophage for modulating inflammatory bowel disease
AssigneesKeio University, Biomx Ltd.
InventorsKenya Honda, Koji Atarashi, Seiko Narushima, Efrat Khabra, Hava Ben David, Eyal Weinstock, Yulia Matiuhin, Naomi Bluma Zak
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Abstract
Disclosed herein are bacteriophage compositions and therapeutic uses thereof. The disclosure also relates to bacteriophage that are capable of lysing Klebsiella bacterial strains, e.g., strains that are associated with inflammatory bowel disease, and thereby capable of modulating disease.
Claims13
A method of treating an inflammatory bowel disease comprising administering to a subject in need thereof a pharmaceutical composition comprising a pharmaceutically acceptable carrier;
- and lytic bacteriophages selected from at least three of the following groups:
- a) Group 1:
- 1.2-2, colon-11, PKP-55, or a family Myoviridae, subfamily Tevenvirinae, genus Kp15 virus that is capable of infecting at least two of Klebsiella pneumoniae strains:
- KP2, CT-123-1, MKP2_21611, and MKP2_251_B;
- b) Group 2:
- M16-7a, KP2-4a, M16-4a, colon-36, KP2-5-1, 1.2-4br, 1.2-4s, M16-6c, KP2-9a, M16-9a, KP2-5a, colon-14-15, colon-6, colon1, M16-3-2c, M16-5c, or a family Myoviridae, subfamily Tevenvirinae, genus T4 virus that is capable of infecting at least two of Klebsiella pneumoniae strains:
- KP2, CT-123-1, MKP2_2161 1, and MKP2_251_B;
- c) Group 3:
- KP2-15-2-1, KP2-14, KP2-15-1, colon-14, 1.2-3b, KP2-8c, KP2-7c, KP2-7-1c, KP2-8a, KP2-5, KP2-16-1, or a Podoviridae, subfamily Autographivirinae, genus T7 virus that is capable of infecting Klebsiella pneumoniae strains KP2 and MKP2_251_B;
- d) Group 4:
- MCoc4c, MCoc6c, Mcoc7c, MCoc3c, MCoc5c, MCoc15c, MCoc8a, MCoc9-2c, M16-9-1c, MCoc9-1c, or Podoviridae, subfamily Autographivirinae, genus Kp34 virus that is capable of infecting at least three of Klebsiella pneumoniae strains:
- CT-141-1, CT-123-1, MKP2_2161 1, and MKP2_251_C;
- e) Group 5:
- 8M-8, or a family Myoviridae, subfamily Vequintavirinae, genus Sc1 virus that is capable of infecting Klebsiella pneumoniae strains CT-123-1, MKP2_2161_1, and 8M-all;
- and
- f) Group 6:
- 8M-1, 8M-7, 1.2-3s or a Siphoviridae that is capable of infecting at least two of Klebsiella pneumoniae strains:
- KP2, CT-123-1, MKP2_2161_1, MKP2_251_B, and 8M-all, wherein the composition is capable of lysing each of Klebsiella pneumoniae strain KP2, and at least four Klebsiella pneumoniae strains selected from CT-141-1, CT-123-1, MKP2_2161_1, MKP2_251_B, MKP2_251_C and 8M-all.
15 more elements
Dependencies are inferred from the claim text.