Nitric oxide-releasing antibacterial compounds, formulations, and methods pertaining thereto
AssigneeKNOW Bio, LLC
InventorsDrew Folk, Ryan Gerald Anderson, John Kelly Simons, Mona Jasmine Rosales Ahonen, Rebecca Anthouard McDonald
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Abstract
Several embodiments of NO releasing compounds are disclosed. In some embodiments, the structures are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of these structures. The compounds may be tailored to release nitric oxide in a controlled manner and can be useful, for example, for treating or preventing microbial infections, or reducing the microbial load of a microbial infection.
Claims15
A method of treating bronchiectasis associated with a pulmonary microbial infection, comprising administering an effective antimicrobial amount of a compound having the formula:
- wherein:
- X is selected from the group consisting of H or D,
- and M+ is a pharmaceutically-acceptable cation selected from the group consisting of sodium, potassium, lithium, and quaternary ammonium, to a patient in need of treatment thereof,
- wherein the compound is present in a composition formulated for pulmonary administration, and
- wherein the bronchiectasis is associated with a pulmonary bacterial infection caused by one or more bacteria selected from the group consisting of Acetinobacter baumannii, Burkolderia cenocepacia, Escherichia coli, Haemophilus influenza, Mycobacterium abcessus, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pyogenes.
Dependencies are inferred from the claim text.