Ophthalmic drug compositions
AssigneeOxular Limited
InventorsRobert Steven Bley, Stanley R. Conston, Ronald K. Yamamoto, Tien T. Nguyen, John P. Lunsford, Dillon Daniel Martinez, Loc X. Phan
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Abstract
The present invention provides a drug composition comprising particles comprising a biodegradable or bioerodable polymer and a drug, a soluble, biodegradable or bioerodible excipient, a bulking agent and a reconstitution aid. The invention also provides a pharmaceutical formulation and a unit dosage form of the pharmaceutical formulation. The invention provides methods of treatment of a disease or condition accordingly. The invention also provides a drug composition for use in a cannulation device.
Claims26
A sterile aqueous drug composition comprising:
- i) microspheres of biodegradable polymer and a drug, wherein the drug comprises 0.5 wt % to 70.0 wt % of the weight of the microspheres, wherein the microspheres have a mean diameter of 1 micron to 100 microns;
- ii) sodium hyaluronate at a concentration of 0.3 to 90.0 wt %;
- and
- iii) an excipient selected from the group consisting of mannitol, maltitol, sorbitol, maltose, lactose, glucose, fructose, galactose, sucrose, and dextran, or combinations thereof present in an amount from 5.0 wt % to 50.0 wt %;
- wherein the composition forms a suspension of microspheres in a concentration range of 70 to 200 mg per ml in an aqueous vehicle.
Dependencies are inferred from the claim text.