Methods of detection of compound, antibody or protein using recombinant endospores or bacteria as sensing element
AssigneeNational Taipei University of Technology
InventorShao-Yi Hou
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Abstract
The present invention provides a method and a system for detecting the presence of an analyte in a sample. In particular, the present invention provides a system, such as a diagnostic kit, for detecting the presence of an analyte in a sample, comprising (a) a recombinant bacterium or spore expressing one or more recombinant proteins on the surface thereof, wherein the recombinant protein specifically binds to the analyte directly or through a binding agent that specifically binds to the recombinant protein and the analyte, and (b) a signal-producing substance that can be detected.
Claims17
A system for detecting the presence of an analyte in a sample, comprising (a) a recombinant Escherichia coli (E. coli) expressing one or more identical or different recombinant proteins on the surface thereof, wherein at least one of the recombinant proteins specifically binds to the analyte directly or through a binding agent that specifically binds to said recombinant protein and the analyte, and (b) a signal-producing substance that can be detected, and wherein the system is a diagnostic kit.
Dependencies are inferred from the claim text.