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US 12,385,843 B2Granted
Systems and methods for hemostatic analysis
AssigneeLoma Linda University Pathology Medical Group, Inc.
InventorsBrian S. Bull, Karen Hay, John F. Wetteland
Life of this patent
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Abstract
Systems and methods for analysis of a whole blood sample from an individual to determine the platelet function and coagulation status of the individual in a substantially automated and efficient matter. Also provided here are systems, reagent kits, and methods for concurrent assessment of platelet function and coagulation as they interact during hemostasis.
Claims20
A system for analysis of blood samples, comprising:
- a frame defining an analysis chamber;
- a sample analysis assembly received within the analysis chamber,
- the sample analysis assembly containing:
- a carriage moveably supported within the analysis chamber;
- a sample container assembly mounted along the carriage and configured to receive at least one sample container containing a blood sample, the sample container assembly linked to a drive mechanism for rotating the at least one sample container;
- a lighting assembly including a light array arranged adjacent to the sample container assembly in a position to direct light of a selected intensity towards the at least one sample container;
- and
- a camera supported along the carriage at a location inside the sample container assembly, the camera configured to capture a plurality of images of the blood sample,
- wherein movement of the carriage causes the sample container assembly and the camera to move together in a substantially coordinated motion, and wherein the motion of the carriage and rotating of the at least one sample container provides a complex motion to the blood sample and is configured to facilitate platelet aggregation, platelet adhesion to the inner aspect of the sample container, or both.
6 more elements
An image analysis system for determining platelet function and coagulation status of a blood sample, comprising:
- a frame delivering an analysis chamber;
- a sample analysis assembly received within the analysis chamber,
- the sample analysis assembly containing:
- a carriage moveably supported within the analysis chamber;
- a sample container assembly mounted along the carriage and configured to receive at least one sample container containing a whole blood sample from the individual, the sample container assembly linked to a drive mechanism for rotating the at least one sample container;
- a lighting assembly including a light array arranged adjacent the sample container assembly in a position to direct light of a selected intensity and wavelength toward the at least one sample container;
- a camera supported along the carriage below the sample container assembly, the camera configured to capture a plurality of images of the blood sample,
- wherein movement of the carriage causes at least the sample container assembly and camera to move together in a substantially coordinated motion, and wherein the motion of the carriage and rotating of the at least one sample container provides one or more of a longitudinal rocking motion, lateral motion, or rotational motion in one or more directions to the blood sample therein;
- and
- a controller configured to process the plurality of images of the blood sample from the camera for identifying one or more endpoints of hemostasis occurring in the blood sample and determining hemostasis status of the individual in response to the identification of the one or more endpoints of hemostasis.
7 more elements
Dependencies are inferred from the claim text.