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US 12,385,104 B2Granted
Methods and compositions for detecting transfusion-transmitted pathogens
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsValeria De Giorgi, Robert D. Allison, Harvey J. Alter
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Abstract
Probe sets capable of detecting pathogen nucleic acids in a sample are described. The probe set can be provided on a solid support, such as a microarray. Methods of detecting pathogen nucleic acids in a sample using the probe set are also provided. In some examples, the probes and methods are capable of detecting one or more RNA viruses, one or more DNA viruses, one or more bacterial nucleic acids, and/or one or more protozoan nucleic acids in a sample.
Claims24
A probe set comprising:
- (a) probes having at least 90% identity with the nucleic acid sequences of SEQ ID NOs:
- 1-1300, 1391-1570, and 1691-1769;
- (b) probes having at least 95% identity with the nucleic acid sequences of SEQ ID NOs:
- 1-1300, 1391-1570, and 1691-1769;
- (c) probes comprising the nucleic acid sequence of SEQ ID NOs:
- 1-1300, 1391-1570, and 1691-1769;
- or
- (d) probes comprising the nucleic acid sequence of SEQ ID NOs:
- 1-1769,
- wherein each of the probes is covalently linked to a solid support and each of the probes is 60 nucleotides in length.
7 more elements
Dependencies are inferred from the claim text.