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US 12,385,029 B2Granted
Engineered synthase for production of tryptophan derivatives and intransigent substrates
AssigneeCalifornia Institute of Technology
InventorsDavid K. Romney, Javier Murciano Calles, Jori E. Wehrmuller
Life of this patent
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Abstract
This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.
Claims8
A recombinant tryptophan synthase β-subunit (TrpB) polypeptide comprising the sequence of any one of SEQ ID NOs:
- 14, 16, 18, 20, 22, 24, or 26.
Dependencies are inferred from the claim text.