5-dehydro-2-deoxygluconokinase variant and method for producing 5′-inosinic acid using same
AssigneeDaesang Corporation
InventorsSun Hee Lee, Tae Yeol Choi, Hyun Ho Kim, Dong Hyun Kim, Hyun Sook Kim, Jong Hwan Shin
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Abstract
The present invention relates to a novel 5-dehydro-2-deoxygluconokinase variant and a method of producing 5′-inosinic acid using the same. The 5-dehydro-2-deoxygluconokinase variant is obtained by substituting one or more amino acids in the amino acid sequence constituting 5-dehydro-2-deoxygluconokinase to change the activity of the protein, and a recombinant microorganism comprising the 5-dehydro-2-deoxygluconokinase variant is capable of efficiently producing 5′-inosinic acid.
Claims7
A 5-dehydro-2-deoxygluconokinase variant consisting of the amino acid sequence of SEQ ID NO:
- 2 in which serine at position 146 in the amino acid sequence of SEQ ID NO:
- 4 is substituted with asparagine.
Dependencies are inferred from the claim text.