Cell culture bioreactor
AssigneeABEC, Inc.
InventorsShane Alexander Jaques Kilpatrick, Scott Raymond Pundsack, Moin Ahmed, Megan Logan
Life of this patent
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Abstract
A cell culture bioreactor has perfusion membranes and gas transfer membranes or a gas phase in an extra-membrane space in contact with a film on the perfusion membranes. Gas transfer membranes may travel through the perfusion membranes or through the extra-membrane space. Examples with hollow fiber and flat sheet membranes are shown. One or more of the membranes optionally has a responsive surface, for example a thermo-responsive surface. In some examples, membranes are located in X-Y planes while the length of the reactor extends in a Z-direction.
Claims15
A cell culture bioreactor comprising,
- a plenum to contain a growth media and growing cells;
- a plurality of perfusion membranes within the plenum;
- and,
- a plurality of gas transfer membranes within the plenum,
- wherein ends of the plurality of perfusion membranes and ends of the plurality of gas transfer membranes are held in potting blocks,
- and wherein the potting blocks have arcuate inner faces formed of a solidified potting compound defining portions of the plenum,
- and wherein the plenum is generally cylindrical.
A cell culture bioreactor comprising,
- a plenum to contain a growth media and growing cells;
- a plurality of hollow fiber perfusion membranes within the plenum;
- and,
- a plurality of hollow fiber gas transfer membranes within the plenum;
- wherein the plurality of gas transfer membranes are parallel with the plurality of perfusion membranes and wherein the plurality of gas transfer membranes are potted in first layers of potting material and the plurality of perfusion membranes are potted in second potting layers spaced apart in a direction parallel to the membranes from the first layers of potting material, wherein the second potting layers are located between the first potting layers and the plurality of gas transfer membranes pass through the second potting layers.
Dependencies are inferred from the claim text.