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US 12,384,838 B2Granted
CXCL10 binding proteins and uses thereof
AssigneeHudson Institute of Medical Research
InventorsAndrew N. Stephens, Adam Rainczuk, Sung-Woog Kang
Life of this patent
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Abstract
The present invention relates to C-X-C motif chemokine ligand 10 (CXCL10) binding proteins and uses thereof. The present invention also relates to methods of detecting and/or diagnosing a condition in a subject, comprising determining a level of CXCL10 in the subject.
Claims5
A C-X-C motif chemokine ligand 10 (CXCL10) binding protein, wherein the binding protein binds to full-length human CXCL10, N-terminally truncated CXCL10 and citrullinated CXCL10, wherein the binding protein is an antibody or antigen-binding fragment thereof comprising:
- (i) a heavy chain variable region (VH) comprising:
- a) a complementarity determining region (CDR) 1 comprising a sequence set forth in amino acids 25-34 of SEQ ID NO:
- 11;
- and
- b) a CDR2 comprising a sequence set forth in amino acids 49-65 of SEQ ID NO:
- 11;
- and
- c) a CDR3 comprising a sequence set forth in amino acids 98-108 of SEQ ID NO:
- 11;
- and
- a light chain variable region (VL) comprising:
- a) a CDR1 comprising a sequence set forth in amino acids 23-33 of SEQ ID NO:
- 12;
- and
- b) a CDR2 comprising a sequence set forth in amino acids 49-55 of SEQ ID NO:
- 12;
- and
- c) a CDR3 comprising a sequence set forth in amino acids 88-96 of SEQ ID NO:
- 12;
- or
- (ii) a VH comprising:
- a) a CDR1 comprising a sequence set forth in SEQ ID NO:
- 13;
- and
- b) a CDR2 comprising a sequence set forth in SEQ ID NO:
- 14;
- and
- c) a CDR3 comprising a sequence set forth in SEQ ID NO:
- 15;
- and
- a VL comprising:
- a) a CDR1 comprising a sequence set forth in SEQ ID NO:
- 16;
- and
- b) a CDR2 comprising a sequence of LAS;
- and
- c) a CDR3 comprising a sequence set forth in SEQ ID NO:
- 18.
35 more elements
Dependencies are inferred from the claim text.