US 12,384,806 B2 · Isopaucifloral F phosphate compound and pharmaceutical use thereof

Abstract

The present invention pertains to the technical field of biomedicine, and relates to isopaucifloral F phosphate compounds and pharmaceutical uses thereof. It has been confirmed through experiments that said isopaucifloral F phosphate compounds and pharmaceutically acceptable salts thereof have effects on the bone remodeling process by exerting their anti-osteoporosis efficacy through a dual-mode mechanism of action of promoting osteogenesis and reducing osteoclast resorption, have the characteristics of high bioavailability, stable metabolism and good safety, and can be used to prepare a new generation of anti-osteoporosis drugs.

Claims8

Dependent claims

An isopaucifloral F phosphate compound of the following formula (1) and pharmaceutically acceptable salts thereof:

wherein R1 is independently a phosphate group or a hydrogen atom;
and R2 is independently a phosphate group, wherein the phosphate group is

Dependencies are inferred from the claim text.

Facts

Application

17/908,686Filed 18 Mar 2021

Priority

CN 202010135398.52 Mar 2020

Published

US 2023/0159572 A125 May 2023

Granted

12 Aug 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

C07F 9/095
Esters of phosphoric acids: compounds containing the structure P-O-acyl, P-O-heteroatom, P-O-CN
C07F 9/12
Esters of phosphoric acids: with hydroxyaryl compounds
A61K 31/21
Medicinal preparations containing organic active ingredients: esters, e.g. nitroglycerine, selenocyanates
A61K 31/661
Phosphorus compounds: phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos

Isopaucifloral F phosphate compound and pharmaceutical use thereof

Life of this patent

Isopaucifloral F phosphate compound and pharmaceutical use thereof

Life of this patent

Abstract

Claims8