Inhibitors
AssigneeVivoryon Therapeutics N.V.
InventorsUlrich Heiser, Torsten Hoffmann, Ingeborg Lues, Antje Meyer
Life of this patent
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Abstract
Compounds of formula (I): A-B-D-E or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein: A is monocyclic and bicyclic heteroaryl; B is alkyl, heteroalkyl, alkyl-amino, aryl, heteroaryl, cycloalkyl, heterocyclyl, or alkylene; D is aryl-amino, heteroaryl-amino, cycloalkyl-amino, heterocyclyl, heterocyclyl-amino, urea, thioamide, thiourea, sulfonamide, sulfoximine, or sulfamoyl; and E is aryl, heteroaryl, cycloalkyl, or heterocyclyl. These compounds of formula (I) are inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5).
Claims7
A compound of formula (XIIa):
- wherein
- Z is selected from CH and N;
- Y1 to Y4 and Y6, Y7 and Y10 are CH;
- Y5 is C;
- Y8 and Y9 are C;
- R5 is selected from halogen, alkyl and O-alkyl;
- R6 is selected from hydrogen, alkyl and O-alkyl.
A compound of formula (XIII):
- wherein
- Z is selected from CH and N;
- R5 is selected from halogen, alkyl and O-alkyl;
- and
- R6 is selected from hydrogen, alkyl and O-alkyl.
5-{[2-({3′,4′-dimethoxy-[1,1′-bipheny]-2-yl}amino)ethyl]sulfanyl}-1,3,4-thiadiazol-2-amine.
Dependencies are inferred from the claim text.