Modulators of mas-related g-protein receptor X2 and related products and methods

A method for treating an MRGPR X2 dependent condition by administering to a subject in need thereof an effective amount of a compound having structure (IB):

• or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein:
• R1b is phenyl substituted with Rq;
• each R is independently H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, or alkylamino;
• Rq is —N(R)C(O)R or —N(R)S(O)2R;
• R2 is H;
• R3 is H;
• R4 is H or Cl;
• R5 is H;
• R6 is CF3;
• each Rx is H;
• W is N;
• Z is CRz;
• and
• Rz is H,
• wherein the MRGPR X2 dependent condition is an itch associated condition, and wherein the itch associated condition is urticaria, pruritus, atopic dermatitis, dry skin, psoriasis, contact dermatitis, or eczema.