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US 12,384,744 B2Granted
Enzyme-cleavable methadone prodrugs and methods of use thereof
AssigneeEnsysce Biosciences Inc.
InventorLynn Kirkpatrick
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Abstract
The present disclosure provides methadone prodrugs, pharmaceutical compositions, and their methods of use, where the pharmaceutical compositions comprise a methadone prodrug that provides enzymatically-controlled release of methadone, and an optional enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of methadone from the prodrug so as to attenuate enzymatic cleavage of the prodrug.
Claims3
Compound MD-112, shown below:
- or a salt, hydrate or solvate thereof.
A composition comprising:
- Compound MD-112:
- or a salt, hydrate or solvate thereof;
- and
- a GI enzyme inhibitor.
1 more element
Dependencies are inferred from the claim text.