Method and system for producing sterile solution filled containers

A method for producing sterile solution-filled containers, the method comprising:

• positioning a cartridge onto a filling machine, the cartridge including a plurality of containers, a filter assembly, a connection line in fluid communication with the filter assembly, and a reservoir coupled to the connection line, disposed upstream from the plurality of containers, and disposed downstream from the filter assembly, wherein each of the plurality of containers includes a volume and a stem having a first end in fluid communication with the volume and a second end in fluid communication with the connection line;
• coupling the cartridge to a feed line in fluid communication with a mix tank;
• activating a pump coupled to the feed line;
• at least partially filling one or more of the volumes associated with the plurality of containers by pumping fluid through the feed line, the filter assembly, the reservoir, and the connection line, thereby creating one or more at least partially filled containers;
• sealing the stem of each of the at least partially filled containers at a location between the connection line and the volume of the at least partially filled containers, thereby creating one or more at least partially filled and sealed containers;
• and
• separating each of the at least partially filled and sealed containers from the connection line;
• wherein at least partially filling the one or more of the volumes includes filling a first row of the connection line with a solution, the first row including one or more containers;
• wherein filling the first row of the connection line with the solution comprises:
• filling a first container of the first row including releasing a first valve coupled to the connection line of the first row, and releasing a second valve coupled to a stem of the first container;
• and filling a second container of the first row after opening a third valve coupled to a stem of the second container, and closing the second valve coupled to the stem of the first container;
• and the method further comprising moving a seal and cut assembly in a lateral direction from the first container of the first row to the second container of the first row.

A method for producing sterile solution-filled containers, the method comprising:

• positioning a cartridge onto a filling machine, the cartridge including a plurality of containers, a filter assembly, a connection line in fluid communication with the filter assembly, and a reservoir coupled to the connection line, disposed upstream from the plurality of containers, and disposed downstream from the filter assembly, wherein each of the plurality of containers includes a volume and a stem having a first end in fluid communication with the volume and a second end in fluid communication with the connection line;
• coupling the cartridge to a feed line in fluid communication with a mix tank;
• activating a pump coupled to the feed line;
• at least partially filling one or more of the volumes associated with the plurality of containers by pumping fluid through the feed line, the filter assembly, the reservoir, and the connection line, thereby creating one or more at least partially filled containers;
• sealing the stem of each of the at least partially filled containers at a location between the connection line and the volume of the at least partially filled containers, thereby creating one or more at least partially filled and sealed containers;
• and
• separating each of the at least partially filled and sealed containers from the connection line;
• wherein at least partially filling the one or more of the volumes includes filling a first row of the connection line with a solution, the first row including one or more containers, and filling a second row of the connection line with a solution after separating each of the at least partially filled and sealed containers from the first row of the connection line, the second row being parallel to the first row and including one or more containers;
• and
• moving a seal and cut assembly in a longitudinal direction from the first row toward the second row of the connection line before filling the second row of the connection line.

A method for producing sterile solution-filled containers, the method comprising:

• positioning a cartridge onto a filling machine, the cartridge including a plurality of containers, a filter assembly, a connection line in fluid communication with the filter assembly, and a reservoir coupled to the connection line, disposed upstream from the plurality of containers, and disposed downstream from the filter assembly, wherein each of the plurality of containers includes a volume and a stem having a first end in fluid communication with the volume and a second end in fluid communication with the connection line;
• coupling the cartridge to a feed line in fluid communication with a mix tank;
• activating a pump coupled to the feed line;
• at least partially filling one or more of the volumes associated with the plurality of containers by pumping fluid through the feed line, the filter assembly, the reservoir, and the connection line, thereby creating one or more at least partially filled containers;
• sealing the stem of each of the at least partially filled containers at a location between the connection line and the volume of the at least partially filled containers, thereby creating one or more at least partially filled and sealed containers, wherein sealing the stem comprises:
• capturing the stem with a sealing device, and collecting sealing sensor data by a sensor associated with a seal of the stem;
• analyzing, by one or more processors of a controller, the sensor data associated with the seal;
• and
• identifying, by one or more processors, based on an analysis of the sensor data, a status or condition associated with the seal;
• separating each of the at least partially filled and sealed containers from the connection line;
• and
• rejecting the seal if:
• a direct short is detected in the sealing device by the one or more processors;
• or
• an average weld power, analyzed by the one or more processors, is greater than an upper limit of a stored acceptable weld power range.